概述

  • 产品名称Anti-PHOX2B抗体
    参阅全部 PHOX2B 一抗
  • 描述
    兔多克隆抗体to PHOX2B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide, corresponding to 15 internal sequence amino acids of Human PHOX2B (NP_003915).

  • 阳性对照
    • 293 Cell Lysate.

性能

应用

Our Abpromise guarantee covers the use of ab125046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 32 kDa.

靶标

  • 功能Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
  • 组织特异性Expressed in neuroblastoma, brain and adrenal gland.
  • 疾病相关Defects in PHOX2B are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. Most mutations consist of 5-10 alanine expansions in the poly-Ala region from amino acids 241-260. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.
    Defects in PHOX2B are the cause of susceptibility to neuroblastoma type 2 (NBLST2) [MIM:613013]. A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system.
  • 序列相似性Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • NBLST2 antibody
    • NBPhox antibody
    • Neuroblastoma paired type homeobox protein antibody
    • Neuroblastoma Phox antibody
    • Paired like homeobox 2b antibody
    • Paired mesoderm homeobox 2b antibody
    • Paired mesoderm homeobox protein 2B antibody
    • Paired-like homeobox 2B antibody
    • PHOX 2B antibody
    • PHOX 2B homeodomain protein antibody
    • PHOX2B antibody
    • PHOX2B homeodomain protein antibody
    • PHX2B_HUMAN antibody
    • PMX 2B antibody
    • PMX2B antibody
    see all

Anti-PHOX2B antibody 图像

  • Lane 1 : Anti-PHOX2B antibody (ab125046) at 1 µg/ml
    Lane 2 : Anti-PHOX2B antibody (ab125046) at 2 µg/ml

    Lane 1 : 293 cell lysate
    Lane 2 : 293 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 32 kDa

Anti-PHOX2B antibody (ab125046)参考文献

ab125046 has not yet been referenced specifically in any publications.

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