概述

  • 产品名称Anti-PHOX2A抗体
    参阅全部 PHOX2A 一抗
  • 描述
    小鼠单克隆抗体to PHOX2A
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Recombinant fragment: MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ , corresponding to amino acids 1-91 of Human PHOX2A

性能

应用

Our Abpromise guarantee covers the use of ab54847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 30 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
  • 疾病相关Defects in PHOX2A are the cause of congenital fibrosis of extraocular muscles type 2 (CFEOM2) [MIM:602078]. CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM2 may result from the aberrant development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei.
  • 序列相似性Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
    • Aristaless homeobox gene homolog (Drosophila) antibody
    • Aristaless homeobox homolog antibody
    • Aristaless homeobox protein homolog antibody
    • ARIX 1 homeodomain protein antibody
    • ARIX antibody
    • Arix homeodomain protein antibody
    • ARIX1 homeodomain protein antibody
    • CFEOM 2 antibody
    • CFEOM2 antibody
    • FEOM 2 antibody
    • FEOM2 antibody
    • Fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
    • MGC52227 antibody
    • NCAM 2 antibody
    • NCAM2 antibody
    • Paired like (aristaless) Homeobox 2A antibody
    • Paired like homeobox 2a antibody
    • Paired mesoderm homeobox 2a antibody
    • Paired mesoderm homeobox protein 2A antibody
    • Paired-like homeobox 2A antibody
    • PHOX 2A antibody
    • Phox2 antibody
    • Phox2a antibody
    • PHX2A_HUMAN antibody
    • Pmx 2a antibody
    • Pmx2 antibody
    • Pmx2a antibody
    see all

Anti-PHOX2A antibody 图像



  • Predicted band size : 30 kDa
    PHOX2A antibody (ab54847) at 1ug/lane + PC-12 cell lysate at 25ug/lane.
  • ab54847 at 10 ug/ml staining in human Hela cells by Immunocytochemistry / Immunofluorescence.

Anti-PHOX2A antibody (ab54847)参考文献

This product has been referenced in:
  • Liang H  et al. CtBP2 Downregulation during Neural Crest Specification Induces Expression of Mitf and REST, Resulting in Melanocyte Differentiation and Sympathoadrenal Lineage Suppression. Mol Cell Biol 31:955-70 (2011). WB ; Quail . Read more (PubMed: 21199918) »

See 1 Publication for this product

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