Anti-Phosphoserine Aminotransferase抗体(ab96136)

概述

  • 产品名称Anti-Phosphoserine Aminotransferase抗体
    参阅全部 Phosphoserine Aminotransferase 一抗
  • 描述
    兔多克隆抗体to Phosphoserine Aminotransferase
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Cow
  • 免疫原

    Recombinant protein fragment with a sequence corresponding to a region within amino acids 48 and 298 of Human Phosphoserine Aminotransferase (NP_478059).

  • 阳性对照
    • 293T, A431, H1299, HeLa, HepG2, Molt-4 and Raji cell lines. H1299 whole cell lysate for WB and A549 cells for IF.

性能

应用

Our Abpromise guarantee covers the use of ab96136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
  • 组织特异性Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon.
  • 通路Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.
    Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.
  • 疾病相关Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:610992]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.
  • 序列相似性Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EC 2.6.1.52 antibody
    • Endometrial progesterone induced protein antibody
    • EPIP antibody
    • MGC1460 antibody
    • NLS2 antibody
    • Phosphohydroxythreonine aminotransferase antibody
    • phosphoserine aminotransferase 1 antibody
    • Phosphoserine aminotransferase antibody
    • PSA antibody
    • PSAT antibody
    • Psat1 antibody
    • PSATD antibody
    • SERC_HUMAN antibody
    see all

Anti-Phosphoserine Aminotransferase antibody 图像

  • Anti-Phosphoserine Aminotransferase antibody (ab96136) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 40 kDa
  • ab96136, at 1/200 staining paraformaldehyde-fixed A549 cells by Immunofluorescence (Panel 1) and merged with DNA probe (Panel 2).

Anti-Phosphoserine Aminotransferase antibody (ab96136)参考文献

This product has been referenced in:
  • Kim SK  et al. Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. PLoS One 9:e101004 (2014). WB ; Human . Read more (PubMed: 24979213) »

See 1 Publication for this product

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