Anti-Phospholamban抗体(ab86930)

概述

  • 产品名称Anti-Phospholamban抗体
    参阅全部 Phospholamban 一抗
  • 描述
    兔多克隆抗体to Phospholamban
  • 特异性No cross reactivity with other proteins is observed.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human Phospholamban aa 2-16 (N terminal).
    Sequence:

    EKVQYLTRSAIRRAS


    Database link: P26678

  • 阳性对照
    • Rat heart tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab86930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 6 kDa.

靶标

  • 功能Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
  • 组织特异性Heart muscle (at protein level).
  • 疾病相关Cardiomyopathy, dilated 1P
    Cardiomyopathy, familial hypertrophic 18
  • 序列相似性Belongs to the phospholamban family.
  • 翻译后修饰Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
  • 细胞定位Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Mitochondrion membrane. Membrane. Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cardiac phospholamban antibody
    • CMD1P antibody
    • CMH18 antibody
    • PLB antibody
    • Pln antibody
    • PPLA_HUMAN antibody
    see all

Anti-Phospholamban antibody 图像

  • All lanes : Anti-Phospholamban antibody (ab86930) at 1 µg/ml

    Lane 1 : Rat heart tissue lysate
    Lane 2 : Rat heart tissue lysate


    Predicted band size : 6 kDa
    Observed band size : 11 kDa (why is the actual band size different from the predicted?)

Anti-Phospholamban antibody (ab86930)参考文献

ab86930 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. We have not tested these antibodies in guinea pig and therefore cannot guarantee they will work, however there is high homology between the immunogen and the guinea pig sequence for all three. Normally we predictlikely reac...

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1 - What is the difference between ab86930 and ab85146? Which is more suitable for guinea pig?

- Both antibodies target different areas of t...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"