概述

  • 产品名称Anti-PHLPP2抗体
    参阅全部 PHLPP2 一抗
  • 描述
    山羊多克隆抗体to PHLPP2
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    C-PHEEDRTEPPEEFD

    , corresponding to C terminal amino acids 1307-1320 of Human PHLPP2

  • 阳性对照
    • Human Brain (Amygdala, Hippocampus, Substantia Nigra) lysate

性能

应用

Our Abpromise guarantee covers the use of ab62830 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 147 kDa (predicted molecular weight: 147 kDa).
ELISA 1/32000.

靶标

  • 功能Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
  • 组织特异性In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).
  • 序列相似性Contains 22 LRR (leucine-rich) repeats.
    Contains 1 PH domain.
    Contains 1 PP2C-like domain.
  • 细胞定位Cytoplasm. Membrane. Nucleus. In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KIAA0931 antibody
    • PH domain and leucine rich repeat protein phosphatase 2 antibody
    • PH domain leucine rich repeat protein phosphatase like antibody
    • PH domain leucine-rich repeat-containing protein phosphatase 2 antibody
    • PH domain leucine-rich repeat-containing protein phosphatase-like antibody
    • PHLP2_HUMAN antibody
    • PHLPP like antibody
    • PHLPP-like antibody
    • Phlpp2 antibody
    • PHLPPL antibody
    see all

Anti-PHLPP2 antibody 图像

  • Anti-PHLPP2 antibody (ab62830) at 0.1 µg/ml + Human Brain (Amygdala, Hippocampus, Substantia Nigra) lysate at 35 µg

    Predicted band size : 147 kDa
    Observed band size : 147 kDa

Anti-PHLPP2 antibody (ab62830)参考文献

ab62830 has not yet been referenced specifically in any publications.

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