概述

  • 产品名称Anti-PHF10抗体
    参阅全部 PHF10 一抗
  • 描述
    兔多克隆抗体to PHF10
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Chicken, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide: LDPELPALDS DGDSDDGEDG RGDEKRKNKG TSDSSSGNVS EGESPPDSQE , corresponding to internal sequence amino acids 287-336 of Human PHF10

  • 阳性对照
    • Fetal lung lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab80939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/312500.

WB Use a concentration of 1 µg/ml. Predicted molecular weight: 47 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • 序列相似性Belongs to the SAYP family.
    Contains 2 PHD-type zinc fingers.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BAF45a antibody
    • BRG1-associated factor 45a antibody
    • FLJ10975 antibody
    • MGC111009 antibody
    • PHD finger protein 10 antibody
    • PHD finger protein 10, isoform a antibody
    • PHD zinc finger protein XAP135 antibody
    • Phf10 antibody
    • PHF10_HUMAN antibody
    • XAP135 antibody
    see all

Anti-PHF10 antibody 图像

  • Anti-PHF10 antibody (ab80939) at 1 µg/ml (in 5% skim milk / PBS buffer) + Fetal lung lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 47 kDa
    Observed band size : 47 kDa

Anti-PHF10 antibody (ab80939)参考文献

ab80939 has not yet been referenced specifically in any publications.

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