概述

  • 产品名称Anti-Phex抗体
    参阅全部 Phex 一抗
  • 描述
    兔多克隆抗体to Phex
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 1 and 325 of Human Phex.

  • 阳性对照
    • Molt-4 cells

性能

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应用

Our Abpromise guarantee covers the use of ab96072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 86 kDa.

靶标

  • 功能Probably involved in bone and dentin mineralization and renal phosphate reabsorption.
  • 组织特异性Lymphocytes and fetal brain; not in adult brain, placenta, skeletal muscle and pancreas; not in adult and fetal heart, lung, liver and kidney.
  • 疾病相关Defects in PHEX are a cause of X-linked hypophosphatemic rickets (HYP) [MIM:307800]. HYP is an X-linked dominant disorder characterized by impaired phosphate uptake in the kidney, which is likely to be caused by abnormal regulation of sodium phosphate cotransport in the proximal tubules. Clinical manifestations include skeletal deformities, growth failure, craniosynostosis, paravertebral calcifications, pseudofractures in lower extremities, and muscular hypotonia with onset in early childhood. X-linked hypophosphatemic rickets is the most common form of hypophosphatemia with an incidence of 1 in 20000.
  • 序列相似性Belongs to the peptidase M13 family.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HPDR antibody
    • HPDR1 antibody
    • HYP antibody
    • HYP1 antibody
    • LXHR antibody
    • Metalloendopeptidase homolog PEX antibody
    • PEX antibody
    • Phex antibody
    • PHEX_HUMAN antibody
    • Phosphate regulating endopeptidase homolog X linked antibody
    • Phosphate regulating gene with homologies to endopeptidases on the X chromosome antibody
    • Phosphate-regulating neutral endopeptidase antibody
    • Vitamin D-resistant hypophosphatemic rickets protein antibody
    • X-linked hypophosphatemia protein antibody
    • XLH antibody
    see all

Anti-Phex antibody 图像

  • Anti-Phex antibody (ab96072) at 1/1000 dilution + Molt-4 cell lysate at 30 µg

    Predicted band size : 86 kDa

Anti-Phex antibody (ab96072)参考文献

ab96072 has not yet been referenced specifically in any publications.

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