概述

描述

  • 性质Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab6094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明

    Stable for one year.

    Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • Acidic (leucine rich) nuclear phosphoprotein 32 family member B
    • Acidic leucine rich nuclear phosphoprotein 32 family member B
    • Acidic leucine-rich nuclear phosphoprotein 32 family member B
    • Acidic nuclear phosphoprotein 32 family member B
    • Acidic protein rich in leucines
    • AN32B_HUMAN
    • ANP 32B
    • ANP32B
    • APRIL
    • OTTHUMP0000006377
    • PAL 31
    • PAL31
    • PHAPI 2
    • PHAPI2
    • PHAPI2 protein
    • PHAPI2a
    • Proliferation related acidic leucine rich protein
    • Putative HLA-DR-associated protein I-2
    • Silver stainable protein SSP 29
    • Silver stainable protein SSP29
    • Silver-stainable protein SSP29
    • Ssp 29
    • Ssp29
    see all
  • 功能Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
  • 组织特异性Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
  • 序列相似性Belongs to the ANP32 family.
    Contains 4 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
  • 结构域Histone binding is mediated by the concave surface of the LRR region.
  • 翻译后修饰Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
  • 细胞定位Nucleus. Accumulates in the nuclei at the S phase and Cytoplasm. Lacks a nuclear localization signal.
  • Information by UniProt

PHAPI2 / APRIL peptide (ab6094)参考文献

ab6094 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab6094.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"