Anti-PGRMC1抗体(ab48012)
Key features and details
- Goat polyclonal to PGRMC1
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-PGRMC1抗体
参阅全部 PGRMC1 一抗 -
描述
山羊多克隆抗体to PGRMC1 -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat, Cow, Pig -
免疫原
Synthetic peptide:
C-EPKDESARKND
, corresponding to C terminal amino acids 185-195 of Human PGRMC1. -
阳性对照
- WB: Human kidney, liver and testis lysates. Mouse testis.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.05% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab48012于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 0.1 - 0.33 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 22 kDa).
A 1 hour primary incubation at room temperature is recommended for this product. |
说明 |
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WB
Use a concentration of 0.1 - 0.33 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 22 kDa). A 1 hour primary incubation at room temperature is recommended for this product. |
靶标
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功能
Receptor for progesterone. -
组织特异性
Widely expressed, with highest expression in liver and kidney. -
序列相似性
Belongs to the cytochrome b5 family. MAPR subfamily.
Contains 1 cytochrome b5 heme-binding domain. -
结构域
The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131. -
细胞定位
Microsome membrane. Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 317706 Cow
- Entrez Gene: 10857 Human
- Entrez Gene: 53328 Mouse
- Entrez Gene: 396946 Pig
- Entrez Gene: 291948 Rat
- Omim: 300435 Human
- SwissProt: Q17QC0 Cow
- SwissProt: O00264 Human
see all -
别名
- HPR6.6 antibody
- Membrane associated progesterone receptor component 1 antibody
- Membrane-associated progesterone receptor component 1 antibody
see all
图片
实验方案
数据表及文件
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Datasheet download
文献 (15)
ab48012 被引用在 15 文献中.
- Bai Y et al. PGRMC1 Promotes Progestin-Dependent Proliferation of Breast Cancer Cells by Binding Prohibitins Resulting in Activation of ERα Signaling. Cancers (Basel) 13:N/A (2021). PubMed: 34830790
- Furuhata R et al. Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes. Commun Biol 3:479 (2020). PubMed: 32887925
- Salsano S et al. Novel nonclassic progesterone receptor PGRMC1 pulldown-precipitated proteins reveal a key role during human decidualization. Fertil Steril 113:1050-1066.e7 (2020). PubMed: 32386616
- He Y et al. Combined assessment of low PGRMC1/positive ATP1A1 levels has enhanced prognostic value for renal cell carcinoma. Oncol Rep 40:1467-1476 (2018). PubMed: 30015972
- Riad A et al. Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex. Sci Rep 8:16845 (2018). PubMed: 30443021