概述

  • 产品名称Anti-PGC1 beta抗体
    参阅全部 PGC1 beta 一抗
  • 描述
    山羊多克隆抗体to PGC1 beta
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Rhesus monkey, Marmoset (common)
  • 免疫原

    Synthetic peptide: AGNDCGALLDEELS, corresponding to amino acids 2-15 of Human PGC1 beta (NP_573570.3).

  • 阳性对照
    • Human Heart, Human Spleen
  • 常规说明

    This product may be covered by one or more of the following U.S. Patents.

    6,166,192
    6,426,411
    6,525,178
    6,872,391
    6,908,987
    7,250,283
    7,091,006
    7,354,738
    8,105,774
    8,445,233

     

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应用

Our Abpromise guarantee covers the use of ab118603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

靶标

  • 功能Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
  • 组织特异性Ubiquitous with higher expression in heart, brain and skeletal muscle.
  • 序列相似性Contains 1 RRM (RNA recognition motif) domain.
  • 结构域Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PERC antibody
    • peroxisome proliferative activated receptor, gamma, coactivator 1, antibody
    • peroxisome proliferator-activated receptor gamma coactivator 1 beta antibody
    • Peroxisome proliferator-activated receptor gamma coactivator 1-beta antibody
    • peroxisome proliferator-activated receptor gamma, coactivator 1 beta antibody
    • PGC-1(beta) antibody
    • PGC-1-beta antibody
    • PGC-1-related estrogen receptor alpha coactivator antibody
    • PGC1 antibody
    • PPAR gamma coactivator-1beta antibody
    • PPAR-gamma coactivator 1-beta antibody
    • PPARGC-1-beta antibody
    • PPARGC1 antibody
    • Ppargc1b antibody
    • PRGC2_HUMAN antibody
    see all

Anti-PGC1 beta antibody 图像

  • ab118603 at 3.75 µg/ml staining PGC1 beta in Human Heart by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • ab118603 at 3.75 &microg/ml staining PGC1 beta in Human Skeletal Muscle by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-PGC1 beta antibody (ab118603)参考文献

ab118603 has not yet been referenced specifically in any publications.

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