概述

  • 产品名称
    Anti-PGC1 beta抗体
    参阅全部 PGC1 beta 一抗
  • 描述
    山羊多克隆抗体to PGC1 beta
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Rhesus monkey, Common marmoset
  • 免疫原

    Synthetic peptide: AGNDCGALLDEELS, corresponding to amino acids 2-15 of Human PGC1 beta (NP_573570.3).

  • 阳性对照
    • Human Heart, Human Spleen
  • 常规说明

    This product may be covered by one or more of the following U.S. Patents.

    6,166,192
    6,426,411
    6,525,178
    6,872,391
    6,908,987
    7,250,283
    7,091,006
    7,354,738
    8,105,774
    8,445,233

     

应用

Our Abpromise guarantee covers the use of ab118603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

靶标

  • 功能
    Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
  • 组织特异性
    Ubiquitous with higher expression in heart, brain and skeletal muscle.
  • 序列相似性
    Contains 1 RRM (RNA recognition motif) domain.
  • 结构域
    Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PERC antibody
    • peroxisome proliferative activated receptor, gamma, coactivator 1, antibody
    • peroxisome proliferator-activated receptor gamma coactivator 1 beta antibody
    • Peroxisome proliferator-activated receptor gamma coactivator 1-beta antibody
    • peroxisome proliferator-activated receptor gamma, coactivator 1 beta antibody
    • PGC-1(beta) antibody
    • PGC-1-beta antibody
    • PGC-1-related estrogen receptor alpha coactivator antibody
    • PGC1 antibody
    • PPAR gamma coactivator-1beta antibody
    • PPAR-gamma coactivator 1-beta antibody
    • PPARGC-1-beta antibody
    • PPARGC1 antibody
    • Ppargc1b antibody
    • PRGC2_HUMAN antibody
    see all

图片

  • ab118603 at 3.75 µg/ml staining PGC1 beta in Human Heart by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • ab118603 at 3.75 &microg/ml staining PGC1 beta in Human Skeletal Muscle by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

文献

ab118603 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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