概述

  • 产品名称Anti-PGAM2抗体
    参阅全部 PGAM2 一抗
  • 描述
    兔多克隆抗体to PGAM2
  • 特异性The immunogen sequence shows 81% homology with PGAM1, so cross-reactivity with PGAM1 cannot be excluded. However, cross-reactivity has not been tested.
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Pig
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 1-203 of Human PGAM2 (NP_000281)

  • 阳性对照
    • H1299 or HeLa lysates A549 cells (IF)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG

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应用

Our Abpromise guarantee covers the use of ab97800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 29 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
  • 组织特异性In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.
  • 疾病相关Defects in PGAM2 are the cause of glycogen storage disease type 10 (GSD10) [MIM:261670]. A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps and excercise intolerance.
  • 序列相似性Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BPG dependent PGAM 2 antibody
    • BPG-dependent PGAM 2 antibody
    • GSD10 antibody
    • MGC88743 antibody
    • Muscle specific phosphoglycerate mutase antibody
    • Muscle-specific phosphoglycerate mutase antibody
    • OTTHUMP00000207787 antibody
    • PGAM 2 antibody
    • PGAM M antibody
    • PGAM-M antibody
    • Pgam2 antibody
    • PGAM2_HUMAN antibody
    • PGAMM antibody
    • phosphoglycerate mutase 2 (muscle) antibody
    • Phosphoglycerate mutase 2 antibody
    • Phosphoglycerate mutase isozyme M antibody
    see all

Anti-PGAM2 antibody 图像

  • All lanes : Anti-PGAM2 antibody (ab97800) at 1/10000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 29 kDa
  • Immunofluorescence analysis of paraformaldehyde-fixed A549, using ab97800 at 1/200 dilution. Lower image was also merged with DNA probe.

Anti-PGAM2 antibody (ab97800)参考文献

This product has been referenced in:

See 1 Publication for this product

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I am sorry for the unclear information on the datashet. As requested, I have issued a free of cha...

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The lab confirmed that they have not done specificity tests for ab97800 for cross-reactivity with PGAM1. They BLASTed the immunogen sequence with PGAM1, which shows 81% homology, so they could not exclude cro...

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