概述

  • 产品名称Anti-PFTK1抗体
    参阅全部 PFTK1 一抗
  • 描述
    小鼠多克隆抗体to PFTK1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length PFTK1 protein (Human)

  • 阳性对照
    • PFTK1 transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab67997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).

靶标

  • 功能Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
  • 组织特异性Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位Cell membrane. Cytoplasm. Nucleus. Recruited to the cell membrane by CCNY.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cdk14 antibody
    • CDK14_HUMAN antibody
    • Cell division protein kinase 14 antibody
    • Cyclin-dependent kinase 14 antibody
    • hPFTAIRE1 antibody
    • KIAA0834 antibody
    • mKIAA0834 antibody
    • PFTAIRE protein kinase 1 antibody
    • PFTAIRE1 antibody
    • PFTK1 antibody
    • Serine/threonine protein kinase PFTAIRE 1 antibody
    • Serine/threonine-protein kinase PFTAIRE-1 antibody
    see all

Anti-PFTK1 antibody 图像

  • All lanes : Anti-PFTK1 antibody (ab67997) at 1/500 dilution

    Lane 1 : PFTK1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 53 kDa
    Observed band size : 53 kDa

Anti-PFTK1 antibody (ab67997)参考文献

ab67997 has not yet been referenced specifically in any publications.

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