概述

  • 产品名称Anti-PEX7抗体
    参阅全部 PEX7 一抗
  • 描述
    兔多克隆抗体to PEX7
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide derived from the internal region of Human PEX7.

  • 阳性对照
    • Extracts from NIH/3T3 cells. Human breast carcinoma tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab92779 was affinity-purified from rabbit antiserum by affinity-chromatography using an epitope-specific immunogen
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab92779 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
IHC-P
  • 应用说明ELISA: 1/40000.
    IHC-P: 1/50 - 1/100.
    WB: 1/500 - 1/1000. Predicted molecular weight: 36 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.
    • 组织特异性Ubiquitous. Highest expression in pancreas, skeletal muscle and heart.
    • 疾病相关Defects in PEX7 are the cause of peroxisome biogenesis disorder complementation group 11 (PBD-CG11) [MIM:614879]. PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 13 distinct genetic groups as concluded from complementation studies.
      Defects in PEX7 are the cause of rhizomelic chondrodysplasia punctata type 1 (RCDP1) [MIM:215100]. RCDP1 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation.
      Defects in PEX7 are the cause of peroxisome biogenesis disorder 9B (PBD9B) [MIM:614879]. A peroxisome biogenesis disorder with unusually mild clinical and biochemical manifestations. Affected individuals manifest a variable phenotype similar to, and in some cases indistinguishable from, classic Refsum disease. Variable features include ocular abnormalities, sensorimotor neuropathy, ichthyosis, deafness, chondrodysplasia punctata without rhizomelia or growth failure.
    • 序列相似性Belongs to the WD repeat peroxin-7 family.
      Contains 6 WD repeats.
    • 细胞定位Peroxisome. Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • PBD9B antibody
      • PCDP1 antibody
      • Peroxin 7 antibody
      • Peroxin-7 antibody
      • Peroxisomal PTS2 receptor antibody
      • Peroxisomal targeting signal 2 receptor antibody
      • Peroxisome biogenesis factor 7 antibody
      • Peroxisome targeting signal 2 receptor antibody
      • PEX7 antibody
      • PEX7 protein antibody
      • PEX7_HUMAN antibody
      • PTS2 receptor antibody
      • PTS2R antibody
      • RCDP1 antibody
      • RD antibody
      see all

    Anti-PEX7 antibody 图像

    • ab92779, at 1/50 dilution, staining PEX7 in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry in the presence (right panel) or absence (left panel) of immunising peptide.
    • All lanes : Anti-PEX7 antibody (ab92779) at 1/500 dilution

      Lane 1 : Extracts from NIH/3T3 cells
      Lane 2 : Extracts from NIH/3T3 cells with immunising peptide at 10 µg

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 36 kDa

    Anti-PEX7 antibody (ab92779)参考文献

    ab92779 has not yet been referenced specifically in any publications.

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