概述

  • 产品名称Anti-PEX2抗体
    参阅全部 PEX2 一抗
  • 描述
    山羊多克隆抗体to PEX2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Chinese Hamster
  • 免疫原

    Synthetic peptide (

    C-NATVGQSVLNIKYKN

    ) corresponding to internal sequence amino acids 73-87 of Human PEX2 (NP_000309.1).

  • 阳性对照
    • HeLa lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab101722 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab101722 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).

靶标

  • 功能Somewhat implicated in the biogenesis of peroxisomes.
  • 疾病相关Defects in PEX2 are the cause of peroxisome biogenesis disorder complementation group 5 (PBD-CG5) [MIM:170993]; also known as PBD-CGF. PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies.
    Defects in PEX2 are a cause of Zellweger syndrome (ZWS) [MIM:214100]. ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. Death occurs within the first year of life.
    Defects in PEX2 are a cause of infantile Refsum disease (IRD) [MIM:266510]. IRD is a mild peroxisome biogenesis disorder (PBD). Clinical features include early onset, mental retardation, minor facial dysmorphism, retinopathy, sensorineural hearing deficit, hepatomegaly, osteoporosis, failure to thrive, and hypocholesterolemia. The biochemical abnormalities include accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid.
  • 序列相似性Belongs to the pex2/pex10/pex12 family.
    Contains 1 RING-type zinc finger.
  • 细胞定位Peroxisome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 35 kDa peroxisomal membrane protein antibody
    • PAF-1 antibody
    • PAF1 antibody
    • Peroxin-2 antibody
    • peroxisomal biogenesis factor 2 antibody
    • Peroxisomal membrane protein 3 antibody
    • peroxisomal membrane protein 3, 35kDa antibody
    • Peroxisome assembly factor 1 antibody
    • Peroxisome biogenesis factor 2 antibody
    • PEX2 antibody
    • PEX2_HUMAN antibody
    • PMP3 antibody
    • PMP35 antibody
    • PXMP3 antibody
    • RING finger protein 72 antibody
    • RNF72 antibody
    • ZWS3 antibody
    see all

Anti-PEX2 antibody 图像

  • Anti-PEX2 antibody (ab101722) at 0.5 µg/ml + HeLa lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 35 kDa
    Observed band size : 35 kDa

Anti-PEX2 antibody (ab101722)参考文献

ab101722 has not yet been referenced specifically in any publications.

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