• 产品名称
  • 描述
    兔多克隆抗体to PEX19
  • 宿主
  • 经测试应用
    适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 1 - 269 of Human PEX19 (NP_002848).

  • 阳性对照
    • WB: MOLT4 whole cell lysate; ICC/IF: A549 cell IHC-P: SW480 xenograft



Our Abpromise guarantee covers the use of ab95959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 33 kDa.
IHC-P 1/100 - 1/500.
ICC/IF 1/100 - 1/200.


  • 功能
    Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
  • 组织特异性
    Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form.
  • 疾病相关
    Defects in PEX19 are the cause of peroxisome biogenesis disorder complementation group 14 (PBD-CG14) [MIM:600279]; also known as PBD-CGJ. PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies.
    Defects in PEX19 are a cause of Zellweger syndrome (ZWS) [MIM:214100]. ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. Death occurs within the first year of life.
  • 序列相似性
    Belongs to the peroxin-19 family.
  • 细胞定位
    Cytoplasm. Peroxisome membrane. Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 33 kDa housekeeping protein antibody
    • D1S2223E antibody
    • HK33 antibody
    • Housekeeping gene 33kD antibody
    • OK/SW-cl.22 antibody
    • PBD12A antibody
    • Peroxin 19 antibody
    • Peroxin-19 antibody
    • Peroxisomal biogenesis factor 19 antibody
    • Peroxisomal farnesylated protein antibody
    • PEX19 antibody
    • PEX19_HUMAN antibody
    • PMP1 antibody
    • PMPI antibody
    • PXF antibody
    • PXMP1 antibody
    see all


  • Anti-PEX19 antibody (ab95959) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size: 33 kDa

    12% SDS PAGE
  • ab95959, at a 1/200 dilution, staining PEX19 in paraformaldehyde fixed A549 cell by Immunofluorescence analysis.
    Image on the right: merged with DNA probe.
  • ab95959, at a 1/500 dilution, staining PEX19 in paraffin embedded SW480 xenograft by Immunohistochemistry.


ab95959 has not yet been referenced specifically in any publications.


Thank you for your email.

I have checked the sequence homology between human and T brucei. proteins. Unfortunately, the sequences does not show any kind of homology at all so it will be difficult to predict the corss-reactivity of PEX19 antib...

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As discussed please send the T. Brucei sequence details to us by replying this email.

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