概述

  • 产品名称Anti-PEX14抗体
    参阅全部 PEX14 一抗
  • 描述
    兔多克隆抗体to PEX14
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 250-300 of Human PEX14 (NP_004556.1).

  • 阳性对照
    • HeLa whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab113286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17.
    • 疾病相关Defects in PEX14 are the cause of peroxisome biogenesis disorder complementation group K (PBD-CGK) [MIM:601791]. PBD-CGK is a peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS).
      Defects in PEX14 are a cause of Zellweger syndrome (ZWS) [MIM:214100]. ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. Death occurs within the first year of life.
    • 序列相似性Belongs to the peroxin-14 family.
    • 细胞定位Peroxisome membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • dJ734G22.2 antibody
      • NAPP2 antibody
      • NF E2 associated polypeptide 2 antibody
      • Peroxin 14 antibody
      • Peroxin-14 antibody
      • Peroxisomal biogenesis factor 14 antibody
      • Peroxisomal membrane anchor protein PEX14 antibody
      • Peroxisomal membrane anchor protein Pex14p antibody
      • Peroxisomal membrane protein PEX14 antibody
      • pex14 antibody
      • PEX14_HUMAN antibody
      • Pex14p antibody
      • PTS1 receptor docking protein antibody
      • PTS1 receptor-docking protein antibody
      see all

    Anti-PEX14 antibody 图像

    • Staining of PEX14 in HeLa whole cell lysate immunoprecipitated using ab113286 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Lane 2: controle IgG. Predicted band size : 41 kDa. Exposure time: 10 seconds.

    Anti-PEX14 antibody (ab113286)参考文献

    ab113286 has not yet been referenced specifically in any publications.

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