概述

  • 产品名称Anti-PER2抗体
    参阅全部 PER2 一抗
  • 描述
    山羊多克隆抗体to PER2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    C-DQQPKAPLTRDE

    with a Cysteine residue linker, corresponding to amino acids 1029-1040 of Human PER2 (NP_073728.1).

  • 阳性对照
    • Human heart and placenta tissues.

性能

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应用

Our Abpromise guarantee covers the use of ab118489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

靶标

  • 功能Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK
    NPAS2-BMAL1
    BMAL2-induced transactivation.
  • 组织特异性Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low level in lung.
  • 疾病相关Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • 序列相似性Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
  • 翻译后修饰Phosphorylated by CSNK1E and CSNK1D. Phosphorylation results in PER2 protein degradation.
  • 细胞定位Nucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Circadian clock protein PERIOD 2 antibody
    • FASPS antibody
    • FASPS1 antibody
    • hPER 2 antibody
    • hPER2 antibody
    • KIAA0347 antibody
    • OTTHUMP00000164476 antibody
    • PER 2 antibody
    • PER2 antibody
    • PER2_HUMAN antibody
    • Period 2 antibody
    • Period 2 isoform 1 antibody
    • Period circadian clock 2 antibody
    • Period circadian protein 2 antibody
    • Period circadian protein homolog 2 antibody
    • Period homolog 2 (Drosophila) antibody
    • Period homolog 2 antibody
    • Period, Drosophila, homolog of, 2 antibody
    • Period2 antibody
    see all

Anti-PER2 antibody 图像

  • ab118489 at 7.5µg/ml staining PER2 in Formalin-fixed, Paraffin-embedded Human heart tissue by Immunohistochemistry.
  • ab118489 at 7.5µg/ml staining PER2 in Formalin-fixed, Paraffin-embedded Human placenta tissue by Immunohistochemistry.

Anti-PER2 antibody (ab118489)参考文献

ab118489 has not yet been referenced specifically in any publications.

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