Anti-PER1抗体[2715C2] (ab58886)

概述

  • 产品名称Anti-PER1抗体[2715C2]
    参阅全部 PER1 一抗
  • 描述
    小鼠单克隆抗体[2715C2] to PER1
  • 经测试应用适用于: Dot blot, WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment of Human PER1

性能

应用

Our Abpromise guarantee covers the use of ab58886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 136 kDa. Antibody has only been tested on the recombinant fragment (immunogen). We have no data regarding endogenous samples.

靶标

  • 功能Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK
    NPAS2-BMAL1
    BMAL2-induced transactivation.
  • 组织特异性Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle. Low level in kidney.
  • 序列相似性Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
  • 翻译后修饰Phosphorylated on serine residues by CSNK1E. Also can be phosphorylated by the delta isoform. Phosphorylation by CSNK1 retains PER1 in the cytoplasm and leads to its ubiquitination and subsequent degradation. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Ubiquitinated.
  • 细胞定位Nucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Circadian clock protein PERIOD 1 antibody
    • Circadian clock protein PERIOD1 antibody
    • Circadian pacemaker protein Rigui antibody
    • hPER 1 antibody
    • hPER antibody
    • hPER1 antibody
    • KIAA0482 antibody
    • MGC88021 antibody
    • PER 1 antibody
    • PER antibody
    • PER1 antibody
    • PER1 protein antibody
    • PER1_HUMAN antibody
    • Period 1 antibody
    • Period circadian protein homolog 1 antibody
    • Period drosophila homolog of antibody
    • Period homolog 1 antibody
    • Period1 antibody
    • RIGUI antibody
    see all

Anti-PER1 antibody [2715C2] 图像

  • Anti-PER1 antibody [2715C2] (ab58886) + immunising recombinant fragment

    Predicted band size : 136 kDa

Anti-PER1 antibody [2715C2] (ab58886)参考文献

ab58886 has not yet been referenced specifically in any publications.

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