概述

  • 产品名称Anti-PEPD抗体
    参阅全部 PEPD 一抗
  • 描述
    兔多克隆抗体to PEPD
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 360-409 (GAVFMPHGLG HFLGIDVHDV GGYPEGVERI DEPGLRSLRT ARHLQPGMVL) of human PEPD (NP_000276).

  • 阳性对照
    • Human placenta lysate

性能

应用

Our Abpromise guarantee covers the use of ab86507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
  • 疾病相关Defects in PEPD are a cause of prolidase deficiency (PD) [MIM:170100]. Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage between the polymorphisms of prolidase and the myotonic dystrophy trait.
  • 序列相似性Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aminoacyl L proline hydrolase antibody
    • Imidodipeptidase antibody
    • MGC10905 antibody
    • MGC95081 antibody
    • Pep 4 antibody
    • Pep4 antibody
    • pepD antibody
    • PEPD_HUMAN antibody
    • Peptidase 4 antibody
    • Peptidase D antibody
    • Prolidase antibody
    • Proline dipeptidase antibody
    • X pro dipeptidase antibody
    • X-Pro dipeptidase antibody
    • Xaa-Pro dipeptidase antibody
    see all

Anti-PEPD antibody 图像

  • Anti-PEPD antibody (ab86507) at 1 µg/ml + human placenta lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size : 55 kDa
    Observed band size : 55 kDa

Anti-PEPD antibody (ab86507)参考文献

This product has been referenced in:
  • Pohl MO  et al. Prolidase is required for early trafficking events during influenza A virus entry. J Virol 88:11271-83 (2014). Read more (PubMed: 25031340) »
  • Yang L  et al. Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling. J Biol Chem 288:2365-75 (2013). WB, ELISA . Read more (PubMed: 23212918) »

See all 2 Publications for this product

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