Anti-PEN2抗体(ab109619)

概述

  • 产品名称Anti-PEN2抗体
    参阅全部 PEN2 一抗
  • 描述
    兔多克隆抗体to PEN2
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    KLH conjugated synthetic peptide of 13 amino acids in length from near the N-terminus of Human PEN2.

  • 阳性对照
    • A20 cell lysate, Human adrenal, placenta and thymus tissue

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab109619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 12 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
  • 组织特异性Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
  • 序列相似性Belongs to the PEN-2 family.
  • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Gamma secretase subunit PEN 2 antibody
    • Gamma Secretase Subunit PEN2 antibody
    • Gamma-secretase subunit PEN-2 antibody
    • Hematopoietic stem/progenitor cells protein MDS033 antibody
    • MDS033 antibody
    • MSTP064 antibody
    • PEN 2 antibody
    • PEN2_HUMAN antibody
    • Presenilin Enhancer 2 antibody
    • Presenilin enhancer 2 homolog antibody
    • Presenilin enhancer protein 2 antibody
    • PSEN2 antibody
    • psenen antibody
    see all

Anti-PEN2 antibody 图像

  • Lane 1 : Anti-PEN2 antibody (ab109619) at 0.5 µg/ml
    Lane 2 : Anti-PEN2 antibody (ab109619) at 1 µg/ml

    Lane 1 : A20 cell lysate
    Lane 2 : A20 cell lysate


    Predicted band size : 12 kDa
  • Human adrenal tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.
  • Human thymus tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.
  • Human placenta tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.

Anti-PEN2 antibody (ab109619)参考文献

ab109619 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citric acid
Sample Human Tissue sections (Breast carcinoma)
Specification Breast carcinoma
Permeabilization No
Fixative Formaldehyde
Username

Mr. Carl Hobbs

Verified customer

提交于 May 29 2013

Thank you for the additional information.

I can now confirm that the Anti-PEN2 antibody would bind N-terminal to the mutation at residue 23.

I hope that this information is helpful. Please do contact me if you have any additional q...

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Thank you for contacting us yesterday in regards to the Anti-Nicastrin antibody (ab45425) and Anti-PEN2 antibody (ab109619).

As discussed over the phone, I have requested further information regarding the immunogen used to raise the two antib...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"