概述

  • 产品名称Anti-PELP1抗体
    参阅全部 PELP1 一抗
  • 描述
    兔多克隆抗体to PELP1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region within the amino acids 1000-1050 of Human MNAR (accession number: AAN41255.1)

  • 阳性对照
    • Human breast adenocarcinoma. Mouse ovary tissue.

性能

应用

Our Abpromise guarantee covers the use of ab84094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.
    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K.
    • 组织特异性Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed.
    • 结构域The Glu-rich region mediates histones interaction.
      The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus. Cytoplasm. Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors.
    • Information by UniProt
    • 数据库链接
    • 别名
      • glutamic acid- and leucine-rich protein 1 antibody
      • HMX3 antibody
      • MNAR antibody
      • Modulator of non-genomic activity of estrogen receptor antibody
      • Modulator of nongenomic activity of estrogen receptor antibody
      • P160 antibody
      • Pelp1 antibody
      • PELP1 proline glutamic acid leucine rich protein 1 antibody
      • PELP1_HUMAN antibody
      • proline and glutamic acid rich nuclear protein antibody
      • Proline glutamate and leucine rich protein 1 antibody
      • Proline- antibody
      • proline-, glutamic acid- and leucine-rich protein 1 antibody
      • Transcription factor HMX3 antibody
      see all

    Anti-PELP1 antibody 图像

    • Detection of Human MNAR by Immunohistochemistry.
      Sample: FFPE section of Human breast adenocarcinoma.
      Antibody: ab84094 used at a dilution of 1/500.
    • Detection of Mouse MNAR by Immunohistochemistry.
      Sample: FFPE section of Mouse ovary.
      Antibody:ab84094 used at a dilution of 1/100.
      Detection: DAB.

    Anti-PELP1 antibody (ab84094)参考文献

    This product has been referenced in:
    • Janssen SF  et al. Gene expression and functional annotation of the human ciliary body epithelia. PLoS One 7:e44973 (2012). IHC-FoFr ; Human . Read more (PubMed: 23028713) »

    See 1 Publication for this product

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