1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
功能Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity.
序列相似性Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
结构域The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity.