概述

  • 产品名称
    Anti-PEAR1抗体
  • 描述
    兔多克隆抗体to PEAR1
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: PSDPNTCSFW ESFTTTTKES HSRPFSLLPS EPCERPWEGP HTCPQPTVVY RTVYRQVVKT DHRQRLQCCH GFYES, corresponding to amino acids 23-97 of Human.

  • 阳性对照
    • Human bone marrow tissue.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab122261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
  • 组织特异性
    Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.
  • 序列相似性
    Belongs to the MEGF family.
    Contains 9 EGF-like domains.
    Contains 1 EMI domain.
  • 翻译后修饰
    Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.
  • 细胞定位
    Cell membrane. Detected on the cell surface in resting platelets.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hPEAR1 antibody
    • JEDI antibody
    • MEGF12 antibody
    • Multiple EGF-like domains protein 12 antibody
    • Multiple epidermal growth factor-like domains protein 12 antibody
    • Pear1 antibody
    • PEAR1_HUMAN antibody
    • Platelet endothelial aggregation receptor 1 antibody
    • RP11-107D16.3 antibody
    see all

图片

  • ab122261, at 1/35, staining PEAR1 in paraffin embedded Human bone marrow tissue by Immunohistochemistry.

文献

ab122261 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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