Anti-PEA15 (phospho S116)抗体(ab59216)

概述

  • 产品名称Anti-PEA15 (phospho S116)抗体
    参阅全部 PEA15 一抗
  • 描述
    兔多克隆抗体to PEA15 (phospho S116)
  • 特异性ab59216 detects endogenous levels of PEA 15 only when phosphorylated at serine 116.
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from human PEA 15 (SwissProt Q15121) around the phosphorylation site of serine 116 (Q-P-SP-E-E).

  • 阳性对照
    • Human skeletal muscle tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab59216 was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab59216 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
  • 组织特异性Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
  • 序列相似性Contains 1 DED (death effector) domain.
  • 翻译后修饰Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
  • 细胞定位Cytoplasm. Associated with microtubules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 15 kDa phosphoprotein enriched in astrocytes antibody
    • Astrocytic phosphoprotein PEA 15 antibody
    • Astrocytic phosphoprotein PEA-15 antibody
    • Astrocytic phosphoprotein PEA15 antibody
    • HMAT 1 antibody
    • HMAT1 antibody
    • Homolog of mouse MAT 1 oncogene antibody
    • Homolog of mouse MAT1 oncogene antibody
    • HUMMAT 1H antibody
    • HUMMAT1H antibody
    • MAT 1 antibody
    • MAT 1H antibody
    • MAT1 antibody
    • MAT1H antibody
    • PEA 15 antibody
    • Pea15 antibody
    • PEA15 protein antibody
    • PEA15_HUMAN antibody
    • PED antibody
    • Phosphoprotein enriched in astrocytes 15 antibody
    • Phosphoprotein enriched in astrocytes 15kD antibody
    • Phosphoprotein enriched in diabetes antibody
    see all

Anti-PEA15 (phospho S116) antibody 图像

  • ab59216 at 1/50 - 1/100 dilution staining PEA 15 in human skeletal muscle by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

Anti-PEA15 (phospho S116) antibody (ab59216)参考文献

ab59216 has not yet been referenced specifically in any publications.

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