概述

  • 产品名称Anti-PEA15 (phospho S116)抗体
    参阅全部 PEA15 一抗
  • 描述
    兔多克隆抗体to PEA15 (phospho S116)
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic phosphopeptide derived from a region of human PED/PEA-15 that contains serine 116.

  • 阳性对照
    • Cos celss transfected with PED cDNAand stimulated with 100ng/mL PMA;SK-BR-3 cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 50% Glycerol, PBS, 1.0mg/ml BSA. pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from rabbit serum by epitope-specific affinity chromatography. The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated PED/PEA-15. The final product is generated by affinity chromatography using a PED/PEA-15-derived peptide that is phosphorylated at serine 116.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab18032 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 15 kDa (predicted molecular weight: 15 kDa).

靶标

  • 功能Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
  • 组织特异性Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
  • 序列相似性Contains 1 DED (death effector) domain.
  • 翻译后修饰Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
  • 细胞定位Cytoplasm. Associated with microtubules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 15 kDa phosphoprotein enriched in astrocytes antibody
    • Astrocytic phosphoprotein PEA 15 antibody
    • Astrocytic phosphoprotein PEA-15 antibody
    • Astrocytic phosphoprotein PEA15 antibody
    • HMAT 1 antibody
    • HMAT1 antibody
    • Homolog of mouse MAT 1 oncogene antibody
    • Homolog of mouse MAT1 oncogene antibody
    • HUMMAT 1H antibody
    • HUMMAT1H antibody
    • MAT 1 antibody
    • MAT 1H antibody
    • MAT1 antibody
    • MAT1H antibody
    • PEA 15 antibody
    • Pea15 antibody
    • PEA15 protein antibody
    • PEA15_HUMAN antibody
    • PED antibody
    • Phosphoprotein enriched in astrocytes 15 antibody
    • Phosphoprotein enriched in astrocytes 15kD antibody
    • Phosphoprotein enriched in diabetes antibody
    see all

Anti-PEA15 (phospho S116) antibody (ab18032)参考文献

This product has been referenced in:
  • Mielgo A  et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene 28:3551-62 (2009). ICC/IF ; Human . Read more (PubMed: 19668227) »
  • Callejas-Valera JL  et al. E1a Gene Expression Blocks the ERK1/2 Signaling Pathway by Promoting Nuclear Localization and MKP Up-regulation: IMPLICATION IN v-H-Ras-INDUCED SENESCENCE. J Biol Chem 283:13450-8 (2008). WB . Read more (PubMed: 18316372) »

See all 2 Publications for this product

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