The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明WB: 1/500 - 1/1000. Detects a band of approximately 54 kDa (predicted molecular weight: 61 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
组织特异性Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.
序列相似性Contains 4 PDZ (DHR) domains.
细胞定位Cell membrane. Cytoplasm. Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells.