Anti-PDGFC抗体- C-terminal (ab194504)
Key features and details
- Mouse polyclonal to PDGFC - C-terminal
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-PDGFC抗体- C-terminal
参阅全部 PDGFC 一抗 -
描述
小鼠多克隆抗体to PDGFC - C-terminal -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Chicken -
免疫原
Recombinant fragment (GST-tag) corresponding to Human PDGFC aa 200 to the C-terminus (C terminal). NCBI Accession No. NP_057289.
Database link: Q9NRA1 -
阳性对照
- 293 cell lysate; recombinant Human PDGFC protein (immunogen).
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
Constituent: 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
-
Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab194504于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/2500. Predicted molecular weight: 39 kDa.
|
说明 |
---|
WB
1/500 - 1/2500. Predicted molecular weight: 39 kDa. |
靶标
-
功能
Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis. -
组织特异性
Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes. -
序列相似性
Belongs to the PDGF/VEGF growth factor family.
Contains 1 CUB domain. -
发展阶段
In the fetal kidney, detected in the developing mesangium, ureteric bud epithelium and the undifferentiated mesenchyme (at protein level). -
翻译后修饰
Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.
Sumoylated by SUMO1.
N-glycosylated. -
细胞定位
Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors. - Information by UniProt
-
数据库链接
- Entrez Gene: 395469 Chicken
- Entrez Gene: 56034 Human
- Entrez Gene: 54635 Mouse
- Entrez Gene: 79429 Rat
- Omim: 608452 Human
- SwissProt: Q9I946 Chicken
- SwissProt: Q9NRA1 Human
- SwissProt: Q8CI19 Mouse
see all -
别名
- Fallotein antibody
- hSCDGF antibody
- PDGF-C antibody
see all
图片
-
Anti-PDGFC antibody - C-terminal (ab194504) at 1/1000 dilution + recombinant Human PDGFC protein (immunogen) at 0.2 µg
Developed using the ECL technique.
Predicted band size: 39 kDaPredicted MWt of immunogen: 38.21 KDa.
-
Anti-PDGFC antibody - C-terminal (ab194504) at 1/500 dilution + 293 cell lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 39 kDa
数据表及文件
-
SDS download
-
Datasheet download
文献 (0)
ab194504 尚未被引用在任何文献中。