Anti-PDGFAA + PDGFBB抗体(ab50201)

概述

  • 产品名称Anti-PDGFAA + PDGFBB抗体
  • 描述
    山羊多克隆抗体to PDGFAA + PDGFBB
  • 特异性The antibody reacts with PKBa. It may recognize the PKBß isoform. The sequence is identical in mouse, rat, and bovine PKBa, highly conserved in PKBß, and diverges in the PKB? isoform.
  • 经测试应用适用于: WB, Neutralising, Indirect ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Natural human PDGF

  • 阳性对照
    • PDGF-responsive NR6R-3T3 fibroblasts.

性能

应用

Our Abpromise guarantee covers the use of ab50201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
Neutralising
Indirect ELISA
  • 应用说明I-ELISA: Use at a concentration of 0.25 µg/ml.
    Neut: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
    • 组织特异性Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
    • 疾病相关Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF.
    • 序列相似性Belongs to the PDGF/VEGF growth factor family.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 形式PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Secreted.
    • 别名
      • becaplermin antibody
      • c-sis antibody
      • FLJ12858 antibody
      • PDGF 1 antibody
      • PDGF 2 antibody
      • PDGF B antibody
      • PDGF B chain antibody
      • PDGF subunit B antibody
      • PDGF-2 antibody
      • Pdgfb antibody
      • PDGFB_HUMAN antibody
      • Platelet derived growth factor beta polypeptide antibody
      • platelet-derived growth factor 2 antibody
      • Platelet-derived growth factor B chain antibody
      • Platelet-derived growth factor beta polypeptide antibody
      • Platelet-derived growth factor subunit B antibody
      • Platelet-derived growth factor, beta polypeptide (oncogene SIS) antibody
      • Proto-oncogene c-Sis antibody
      • SIS antibody
      • SSV antibody
      see all

    Anti-PDGFAA + PDGFBB antibody (ab50201)参考文献

    ab50201 has not yet been referenced specifically in any publications.

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