Anti-PDGF Receptor alpha抗体[APA5] (ab90967)

概述

  • 产品名称
    Anti-PDGF Receptor alpha抗体[APA5]
    参阅全部 PDGF Receptor alpha 一抗
  • 描述
    大鼠单克隆抗体[APA5] to PDGF Receptor alpha
  • 经测试应用
    适用于: WB, IHC-Fr, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Fusion protein corresponding to Mouse PDGF Receptor alpha (extracellular). Fusion protein containing the extracellular domain of Mouse PDGF Receptor alpha and the Fc portion of Human IgG1 purified from the culture supernatant of transfected COS1 cells

  • 阳性对照
    • NIH3T3 cells

性能

应用

Our Abpromise guarantee covers the use of ab90967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-Fr
Flow Cyt
  • 应用说明
    Flow Cyt: Use 1µg for 106 cells in a 100 µl total staining volume.
    IHC-Fr: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 123 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    • 组织特异性
      Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
    • 疾病相关
      Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
    • 序列相似性
      Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
      Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • 细胞定位
      Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Alpha-type platelet-derived growth factor receptor antibody
      • CD140 antigen-like family member A antibody
      • CD140a antibody
      • CD140a antigen antibody
      • MGC74795 antibody
      • PDGF alpha chain antibody
      • PDGF-R-alpha antibody
      • PDGFR 2 antibody
      • PDGFR alpha antibody
      • PDGFR2 antibody
      • PDGFRA antibody
      • PDGFRA/BCR fusion antibody
      • PGFRA_HUMAN antibody
      • Platelet derived growth factor receptor 2 antibody
      • Platelet derived growth factor receptor alpha antibody
      • Platelet derived growth factor receptor alpha polypeptide antibody
      • Platelet derived growth factor receptor antibody
      • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody
      • RHEPDGFRA antibody
      see all

    Anti-PDGF Receptor alpha antibody [APA5] 图像

    • Staining of NIH/3T3 cells with 0.5 µg Rat IgG2a control antibody (open histogram) or 0.5 µg of ab90967 (colored histogram) followed by Biotin Anti-Rat IgG secondary antibody. Total viable cells were analysed.

    Anti-PDGF Receptor alpha antibody [APA5] (ab90967)参考文献

    This product has been referenced in:
    • Ntokou A  et al. Characterization of the platelet-derived growth factor receptor-a-positive cell lineage during murine late lung development. Am J Physiol Lung Cell Mol Physiol 309:L942-58 (2015). Read more (PubMed: 26320158) »
    • Galiger C  et al. Phenotypical and ultrastructural features of Oct4-positive cells in the adult mouse lung. J Cell Mol Med 18:1321-33 (2014). IF . Read more (PubMed: 24889158) »

    See all 5 Publications for this product

    Product Wall

    Thank you for contacting Abcam regarding ab90967.


    We have not tested this antibody directly in-house for cross reactivity against CD140b.The clone is APA5 and according to the development paper for this clone, this antibody is specific ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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