Recombinant fragment: RLPQGQKTAA LPRTRGAGLL ESELRDGSGK KVAVADVQFG PMRFHQDQLQ VLLVFTKEDN QCNGFCRACE KAGFKCTVTK EAQAVLACFL, corresponding to amino acids 32-121 of human PDE8A (NP_002596) with a 26 kDa tag.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 93 kDa.
Use at an assay dependent dilution.
功能Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
组织特异性Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.