概述

  • 产品名称Anti-PDE8A抗体
    参阅全部 PDE8A 一抗
  • 描述
    兔多克隆抗体to PDE8A
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic cyclic peptide, corresponding to the mid region of PDE8A.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab14619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IP
  • 应用说明IP: 1/250.
    WB: 1/500. Detects a band of approximately 98-102 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
    • 组织特异性Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
    • 通路Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
    • 序列相似性Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
      Contains 1 PAC (PAS-associated C-terminal) domain.
      Contains 1 PAS (PER-ARNT-SIM) domain.
    • 结构域Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 5''-cyclic phosphodiesterase 8A antibody
      • cAMP specific cyclic nucleotide phosphodiesterase 8A antibody
      • FLJ16150 antibody
      • High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody
      • High affinity cAMP-specific and IBMX-insensitive 3'' antibody
      • HsT19550 antibody
      • PDE 8A antibody
      • PDE8A antibody
      • PDE8A_HUMAN antibody
      • Phosphodiesterase 8A antibody
      • Phosphodiesterase8A antibody
      • Weakly similar to 3'5' cyclic nucleotide phosphodiesterase antibody
      see all

    Anti-PDE8A antibody (ab14619)参考文献

    This product has been referenced in:
    • Kelly MP  et al. Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain. Cell Signal 26:383-397 (2013). Mouse, Rat . Read more (PubMed: 24184653) »

    See 1 Publication for this product

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