概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab5890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PDE6 beta, catalog ab5663. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 5''-cyclic phosphodiesterase subunit beta
    • Congenital stationary night blindness 3 autosomal dominant
    • CSNB 3
    • CSNB3
    • CSNBAD2
    • GMP PDE beta
    • GMP-PDE beta
    • PDE 6 beta
    • PDE 6B
    • PDE6B
    • PDE6B_HUMAN
    • PDEB
    • Phosphodiesterase 6B
    • Phosphodiesterase 6B cGMP specific rod beta
    • Rd 1
    • Rd1
    • Rod cGMP phosphodiesterase beta subunit
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase beta subunit
    • Rod cGMP-specific 3''
    • RP40
    see all
  • 功能This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
  • 疾病相关Defects in PDE6B are the cause of retinitis pigmentosa type 40 (RP40) [MIM:613801]. RP40 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    Defects in PDE6B are a cause of congenital stationary night blindness autosomal dominant type 2 (CSNBAD2) [MIM:163500]; also known as congenital stationary night blindness Rambusch type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.
  • 序列相似性Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • 细胞定位Membrane.
  • Information by UniProt

PDE6 beta peptide (ab5890)参考文献

ab5890 has not yet been referenced specifically in any publications.

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