概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab5862 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human PDE6 alpha, catalog ab5659. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 5''-cyclic phosphodiesterase subunit alpha
    • CGPR A
    • GMP PDE alpha
    • GMP-PDE alpha
    • PDE 6 alpha
    • PDE 6A
    • PDE V B1
    • PDE V-B1
    • PDE6A
    • PDE6A_HUMAN
    • PDEA
    • Phosphodiesterase 6 alpha
    • Phosphodiesterase 6A alpha subunit
    • Phosphodiesterase 6A cGMP specific rod alpha
    • Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit
    • Rod cGMP-specific 3''
    see all
  • 功能This protein participates in processes of transmission and amplification of the visual signal.
  • 疾病相关Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 序列相似性Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • 细胞定位Cell membrane.
  • Information by UniProt

PDE6 alpha peptide (ab5862)参考文献

ab5862 has not yet been referenced specifically in any publications.

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