Anti-PDE6 alpha抗体(ab85308)


  • 产品名称Anti-PDE6 alpha抗体
    参阅全部 PDE6 alpha 一抗
  • 描述
    兔多克隆抗体to PDE6 alpha
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Dog
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 450 - 550 of Human PDE6 alpha.

    (Peptide available as ab95409.)

  • 阳性对照
    • This antibody gave a positive signal in the following whole cell lysates: HeLa; WERI; Y79.



Our Abpromise guarantee covers the use of ab85308 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 95 kDa (predicted molecular weight: 99 kDa).


  • 功能This protein participates in processes of transmission and amplification of the visual signal.
  • 疾病相关Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 序列相似性Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5''-cyclic phosphodiesterase subunit alpha antibody
    • CGPR A antibody
    • GMP PDE alpha antibody
    • GMP-PDE alpha antibody
    • PDE 6 alpha antibody
    • PDE 6A antibody
    • PDE V B1 antibody
    • PDE V-B1 antibody
    • PDE6A antibody
    • PDE6A_HUMAN antibody
    • PDEA antibody
    • Phosphodiesterase 6 alpha antibody
    • Phosphodiesterase 6A alpha subunit antibody
    • Phosphodiesterase 6A cGMP specific rod alpha antibody
    • Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha antibody
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody
    • Rod cGMP-specific 3'' antibody
    see all

Anti-PDE6 alpha antibody 图像

  • All lanes : Anti-PDE6 alpha antibody (ab85308) at 1 µg/ml

    Lane 1 : Y79 (Human retinoblastoma cell line) Whole Cell Lysate
    Lane 2 : WERI (Human Retinoblastoma) Whole Cell Lysate
    Lane 3 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 99 kDa
    Observed band size : 95 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 50 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 2 minutes

Anti-PDE6 alpha antibody (ab85308)参考文献

ab85308 has not yet been referenced specifically in any publications.

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