概述

  • 产品名称
    Anti-PDE6 alpha抗体
    参阅全部 PDE6 alpha 一抗
  • 描述
    兔多克隆抗体to PDE6 alpha
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Sheep, Cow
    预测可用于: Mouse, Chicken, Human
  • 免疫原

    Synthetic peptide corresponding to Human PDE6C aa 16-29.
    Sequence:

    MPQFAKEYFDRKLR


    (Peptide available as ab5863)

  • 阳性对照
    • WB: sheep retinal extract.

性能

应用

Our Abpromise guarantee covers the use of ab5660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 90 kDa.Can be blocked with PDE6C peptide (ab5863).

靶标

  • 功能
    This protein participates in processes of transmission and amplification of the visual signal.
  • 疾病相关
    Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 序列相似性
    Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5''-cyclic phosphodiesterase subunit alpha antibody
    • CGPR A antibody
    • GMP PDE alpha antibody
    • GMP-PDE alpha antibody
    • PDE 6 alpha antibody
    • PDE 6A antibody
    • PDE V B1 antibody
    • PDE V-B1 antibody
    • PDE6A antibody
    • PDE6A_HUMAN antibody
    • PDEA antibody
    • Phosphodiesterase 6 alpha antibody
    • Phosphodiesterase 6A alpha subunit antibody
    • Phosphodiesterase 6A antibody
    • Phosphodiesterase 6A cGMP specific rod alpha antibody
    • Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha antibody
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody
    • Rod cGMP-specific 3'' antibody
    see all

Anti-PDE6 alpha antibody 图像

  • Western blot of PDE6C on sheep retinal extracts using ab5660.

实验方案

Anti-PDE6 alpha antibody (ab5660)参考文献

This product has been referenced in:
  • Iribarne M  et al. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep 7:45962 (2017). WB ; Zebrafish . Read more (PubMed: 28378769) »

See 1 Publication for this product

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