概述

  • 产品名称Anti-PDE5A抗体
    参阅全部 PDE5A 一抗
  • 描述
    小鼠单克隆抗体to PDE5A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 29-139 of Human PDE5A

性能

应用

Our Abpromise guarantee covers the use of ab56505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
    • 组织特异性Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
    • 通路Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
    • 序列相似性Belongs to the cyclic nucleotide phosphodiesterase family.
      Contains 2 GAF domains.
    • 结构域Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B.
    • 翻译后修饰Phosphorylation is regulated by binding of cGMP to the two allosteric sites.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 5''-cyclic phosphodiesterase antibody
      • CGB PDE antibody
      • CGB-PDE antibody
      • CGBPDE antibody
      • cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase antibody
      • cGMP binding cGMP specific 35 cyclic nucleotide phosphodiesterase antibody
      • cGMP binding cGMP specific phosphodiesterase antibody
      • cGMP binding/cGMP specific phosphodiesterase antibody
      • cGMP specific 3'5' cyclic phosphodiesterase antibody
      • cGMP specific phosphodiesterase PDE5A2 antibody
      • cGMP specific phosphodiesterase type 5A antibody
      • cGMP-binding cGMP-specific phosphodiesterase antibody
      • cGMP-specific 3'' antibody
      • CN5A antibody
      • CN5N antibody
      • PDE 5 antibody
      • PDE 5A antibody
      • PDE5 antibody
      • Pde5a antibody
      • PDE5A_HUMAN antibody
      • PDE5A1 antibody
      • Phosphodiesterase 5A antibody
      • Phosphodiesterase 5A cGMP specific antibody
      • Phosphodiesterase isozyme 5 antibody
      see all

    Anti-PDE5A antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56505 PDE5A antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-PDE5A antibody (ab56505)参考文献

    ab56505 has not yet been referenced specifically in any publications.

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