Anti-PDE4DIP抗体(ab121375)

概述

  • 产品名称Anti-PDE4DIP抗体
    参阅全部 PDE4DIP 一抗
  • 描述
    兔多克隆抗体to PDE4DIP
  • 经测试应用适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 26-171 of Human PDE4DIP, isoform 2 (Q5VU43-2).

  • 阳性对照
    • Human duodenum tissue; RT4 and U251 MG lysates.

性能

应用

Our Abpromise guarantee covers the use of ab121375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/250 - 1/500.
IHC-P 1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

靶标

  • 功能May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.
  • 组织特异性Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta.
  • 疾病相关Note=A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.
  • 序列相似性Contains 1 NBPF domain.
  • 发展阶段Expressed in fetal heart.
  • 细胞定位Golgi apparatus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cardiomyopathy associated protein 2 antibody
    • Cardiomyopathy-associated protein 2 antibody
    • CMYA2 antibody
    • MMGL antibody
    • MYOME_HUMAN antibody
    • Myomegalin antibody
    • Pde4dip antibody
    • Phosphodiesterase 4D interacting protein antibody
    • Phosphodiesterase 4D-interacting protein antibody
    see all

Anti-PDE4DIP antibody 图像

  • Immunocytochemistry/Immunofluorescence analysis of A-431 cells labelling PDE4DIP with ab121375 shows positivity in the Golgi apparatus.

  • ab121375 at 1/15 dilution staining PDE4DIP in Paraffin-embedded Human Duodenum tissue by Immunohistochemistry.
  • All lanes : Anti-PDE4DIP antibody (ab121375) at 1/250 dilution

    Lane 1 : RT4 lysate
    Lane 2 : U251 MG lysate
    Lane 3 : Human plasma
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique

Anti-PDE4DIP antibody (ab121375)参考文献

ab121375 has not yet been referenced specifically in any publications.

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