概述

  • 产品名称Anti-PDE4D7抗体
  • 描述
    兔多克隆抗体to PDE4D7
  • 特异性The antibody does not cross reacts with PDE4D1, D2, D3, D4 and D5 variants. It also does not cross react with PDE4A, PDE4B or PDE4C.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide from unique region near N terminal of the PDE4D7 variant. (Rat)

  • 阳性对照
    • Rat cortical membranes.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab14629 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200. Detects a band of approximately 110 kDa.

靶标

  • 相关性Cyclic AMP dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4, D6, D7, and D8; 1, 2). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios, and their activity is regulated in tandem with GPCRs stimulation and selective phosphorylation by PKA and other kinases. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins. Anti PDE4D antibodies are ideal tools for studying regulation, expression, phosphorylation, and protein protein interactions of PDE4D variants employing pull down immunoprecipitation protocol.
  • 数据库链接
  • 别名
    • DPDE3 antibody
    • HSPDE4D antibody
    • PDE43 antibody
    • PDE4D antibody
    • Phosphodiesterase 4D antibody
    • Phosphodiesterase 4D cAMP-specific antibody
    see all

Anti-PDE4D7 antibody 图像

  • Lane 1 : Anti-PDE4D7 antibody (ab14629)
    Lanes 2 - 3 : Anti-PDE4D7 antibody (ab14629) at 1/750 dilution

    Lane 1 : Negative Control
    Lane 2 : Human Rec-PDE4D7 (1 ng)
    Lane 3 : Human Rec-PDE4D7 (10 ng)

Anti-PDE4D7 antibody (ab14629)参考文献

ab14629 has not yet been referenced specifically in any publications.

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