概述

  • 产品名称
    Anti-PDE4D5抗体
  • 描述
    兔多克隆抗体to PDE4D5
  • 特异性
    This antibody does not cross-react with other members of the PDE4D family or with other PDE4 proteins (PDE4A, B and C) or with other PDE family members.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 20 amino acid synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (N terminal).

  • 阳性对照
    • Rat cortical membranes.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab14626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200 - 1/250. Detects a band of approximately 105 kDa.

靶标

  • 相关性
    Cyclic AMP-dependent Phosphodiesterase 4 type D (PDE4D) family includes 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype-variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype-variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation and selective phosphorylation by PKA and other kinases. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short-term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanisms involved protein-protein interactions with cytoskeletal scaffolding proteins.
  • 数据库链接
  • 别名
    • DPDE3 antibody
    • hPDE4D5 antibody
    • PDE4D antibody
    • PDE4DN2 antibody
    • Phosphodiesterase 4D antibody
    • Phosphodiesterase 4D cAMP-specific antibody
    • STRK1 antibody
    see all

实验方案

文献

ab14626 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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