概述

  • 产品名称
  • 描述
    兔多克隆抗体to PDE2A
  • 特异性
    This antibody has no cross reactivity against PDE2B or with other PDE family members tested so far.
  • 经测试应用
    适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide:

    EVPDLDGTRAPVNG CCSL

    , corresponding to C terminal amino acids 897-914 of Mouse PDE2A

  • 阳性对照
    • Rat brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab14604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IP
  • 应用说明
    IP: 1/250.
    WB: 1/500. Detects a band of approximately 95-97 kDa in samples from rat brain.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
    • 组织特异性
      Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
    • 序列相似性
      Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
      Contains 2 GAF domains.
    • 结构域
      GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme.
    • 细胞定位
      Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 5''-cyclic phosphodiesterase antibody
      • cGMP dependent 3'5' cyclic phosphodiesterase antibody
      • cGMP stimulated phosphodiesterase 1 antibody
      • cGMP stimulated phosphodiesterase 4 antibody
      • cGMP-dependent 3'' antibody
      • cGMP-stimulated phosphodiesterase 2 antibody
      • CGS PDE antibody
      • CGS-PDE antibody
      • cGSPDE antibody
      • Cyclic GMP stimulated phosphodiesterase antibody
      • Cyclic GMP-stimulated phosphodiesterase antibody
      • Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase antibody
      • PDE 2A antibody
      • PDE 2A1 antibody
      • PDE 2A4 antibody
      • PDE2A antibody
      • PDE2A_HUMAN antibody
      • PDE2A1 antibody
      • PDE2A4 antibody
      • phosphodiesterase 2A antibody
      • Phosphodiesterase 2A cGMP stimulated antibody
      see all

    文献

    This product has been referenced in:
    • Kallenborn-Gerhardt W  et al. Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. Anesthesiology 121:372-82 (2014). Read more (PubMed: 24758774) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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