概述

  • 产品名称
  • 描述
    兔多克隆抗体to PDE1A
  • 经测试应用
    适用于: IP, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptides (conserved sequence near the N-terminal) unique to PDE1A family members.

  • 阳性对照
    • Rat testis.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab14599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP 1/200.
WB 1/250 - 1/500. Predicted molecular weight: 61 kDa. This antibody labels multiple bands in 65-72 kDa range all believed to be various PDE1A variants expressed in various rat tissues.
IHC-P Use at an assay dependent concentration. PubMed: 19924104

靶标

  • 功能
    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
  • 组织特异性
    Several tissues, including brain, kidney, testes and heart.
  • 序列相似性
    Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3' 5' cyclic nucleotide phosphodiesterase antibody
    • 5''-cyclic nucleotide phosphodiesterase 1A antibody
    • 61 kDa Cam PDE antibody
    • 61 kDa Cam-PDE antibody
    • Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody
    • Calcium/Calmodulin stimulated cyclic nucleotide phosphodiesterase antibody
    • Calcium/calmodulin-dependent 3'' antibody
    • Calmodulin-dependent Phosphodiesterase antibody
    • Cam PDE 1A antibody
    • Cam-PDE 1A antibody
    • CAM-PDE-1A antibody
    • HCAM 1 antibody
    • hCam-1 antibody
    • HCAM1 antibody
    • HSPDE1A antibody
    • MGC26303 antibody
    • PDE 1A antibody
    • PDE1A antibody
    • PDE1A_HUMAN antibody
    • Phosphodiesterase 1A antibody
    • Phosphodiesterase 1A calmodulin dependent antibody
    see all

文献

This product has been referenced in:
  • Kogiso H  et al. A low [Ca(2+)]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia. Pflugers Arch N/A:N/A (2017). Mouse . Read more (PubMed: 28477148) »
  • Giachini FR  et al. Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1. Hypertension 57:655-63 (2011). WB ; Rat . Read more (PubMed: 21282562) »

See all 4 Publications for this product

客户评价及客户问答

Thank you for contacting Abcam.

The peptide for ab14599 has now added been added to the catalogue as PDE1A peptide (ab140070). Also the immnuogen for ab14599 was from human PDE1A N-terminal epitope form *******.
If there is anything else I...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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