Anti-PDCD4 (phospho S457)抗体[9G6] (ab105998)


  • 产品名称Anti-PDCD4 (phospho S457)抗体[9G6]
    参阅全部 PDCD4 一抗
  • 描述
    小鼠单克隆抗体[9G6] to PDCD4 (phospho S457)
  • 特异性ab105998 is specific for Human PDCD4 protein phosphorylated at Ser457. Cross-reactivity with PDCD4 from other sources has not been determined.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Xenopus laevis
  • 免疫原

    Synthetic peptide corresponding to residues surrounding Ser457 of Human PDCD4 (NP_055271).

  • 阳性对照
    • NIH-3T3 cells stimulated with PDGF, Recombinant PDCD4 protein, Human small intestine tissue



Our Abpromise guarantee covers the use of ab105998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/10000. Predicted molecular weight: 62 kDa.
ELISA 1/20000 - 1/100000.
IHC-P 1/1000 - 1/5000.


  • 功能Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
  • 组织特异性Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
  • 序列相似性Belongs to the PDCD4 family.
    Contains 2 MI domains.
  • 结构域Binds EIF4A1 via both MI domains.
  • 翻译后修饰Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
  • 细胞定位Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Death up-regulated gene protein antibody
    • Dug antibody
    • H731 antibody
    • Ma3 antibody
    • MGC33046 antibody
    • MGC33047 antibody
    • Neoplastic transformation inhibitor antibody
    • Neoplastic transformation inhibitor protein antibody
    • Nuclear antigen H731 antibody
    • Nuclear antigen H731 like antibody
    • Nuclear antigen H731 like protein antibody
    • Nuclear antigen H731-like antibody
    • PDCD 4 antibody
    • Pdcd4 antibody
    • PDCD4_HUMAN antibody
    • Programmed cell death 4 antibody
    • programmed cell death 4 (neoplastic transformation inhibitor) antibody
    • Programmed cell death protein 4 antibody
    • Protein 197/15a antibody
    • Protein MA-3 antibody
    • Tis antibody
    • Topoisomerase-inhibitor suppressed protein antibody
    see all

Anti-PDCD4 (phospho S457) antibody [9G6] 图像

  • All lanes : Anti-PDCD4 (phospho S457) antibody [9G6] (ab105998) at 1/2000 dilution

    Lane 1 : NIH-3T3 cells stimulated with 30 ng/ml PDGF (5 min treatment)
    Lane 2 : Unstimulated (non-phosphorylated) NIH 3T3 cells

    HRP conjugated Rabbit anti-Mouse IgG at 1/2000 dilution

    Predicted band size : 62 kDa
  • ab105998 at 1/1000 dilution staining PDCD4 in Human small intestine by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
    The image shows the localization of ab105998 as the precipitated red signal, with a hematoxylin purple nuclear counterstain.

Anti-PDCD4 (phospho S457) antibody [9G6] (ab105998)参考文献

ab105998 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab105998.
Please use the links above to contact us or submit feedback about this product.