概述

  • 产品名称Anti-PD1抗体[J43] (Biotin)
    参阅全部 PD1 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[J43] to PD1 (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Syrian Hamster kidney cell line BKH transfected with Mouse PD1 cDNA

  • 阳性对照
    • Mouse Con-A activated spleen cell suspensions and Mouse PD-1 transfected cells
  • 常规说明


    It is reported that monoclonal antibody J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.

性能

应用

Our Abpromise guarantee covers the use of ab95790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.25µg for 105-8 cells. Staining the cell sample in a final volume of 100 µl is recommended.

靶标

  • 功能Possible cell death inducer, in association with other factors.
  • 疾病相关Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • 序列相似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 发展阶段Induced at programmed cell death.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD279 antibody
    • CD279 antigen antibody
    • hPD 1 antibody
    • hPD l antibody
    • hPD-1 antibody
    • hSLE1 antibody
    • PD 1 antibody
    • PD-1 antibody
    • PD1 antibody
    • PDCD 1 antibody
    • PDCD1 antibody
    • PDCD1_HUMAN antibody
    • Programmed cell death 1 antibody
    • Programmed cell death protein 1 antibody
    • Protein PD 1 antibody
    • Protein PD-1 antibody
    • SLEB2 antibody
    • Systemic lupus erythematosus susceptibility 2 antibody
    see all

Anti-PD1 antibody [J43] (Biotin) (ab95790)参考文献

This product has been referenced in:
  • Ansari MJ  et al. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 198:63-9 (2003). Read more (PubMed: 12847137) »
  • Salama AD  et al. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J Exp Med 198:71-8 (2003). Read more (PubMed: 12847138) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab95790.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"