概述

  • 产品名称Anti-PD-L1抗体[MIH5] (Biotin)
    参阅全部 PD-L1 一抗
  • 描述
    大鼠单克隆抗体[MIH5] to PD-L1 (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Tissue, cells or virus corresponding to Mouse PD-L1. DBA/2 Mouse lymphoma L5178Y transfected with PL-L1 cDNA

  • 阳性对照
    • Mouse C57Bl/6 splenocytes
  • 常规说明


    ab95792 is reported to be a blocking antibody.

性能

应用

Our Abpromise guarantee covers the use of ab95792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.125-0.25µg for 105-8 cells. Staining the cell sample in a final volume of 100 µl is recommended.



ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
  • 组织特异性Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
  • 序列相似性Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 细胞定位Cell membrane and Endomembrane system.
  • Information by UniProt
  • 数据库链接
  • 别名
    • B7 H antibody
    • B7 H1 antibody
    • B7 homolog 1 antibody
    • B7-H1 antibody
    • B7H antibody
    • B7H1 antibody
    • CD 274 antibody
    • CD274 antibody
    • CD274 antigen antibody
    • CD274 molecule antibody
    • MGC142294 antibody
    • MGC142296 antibody
    • OTTHUMP00000021029 antibody
    • PD L1 antibody
    • PD-L1 antibody
    • PD1L1_HUMAN antibody
    • PDCD1 ligand 1 antibody
    • PDCD1L1 antibody
    • PDCD1LG1 antibody
    • PDL 1 antibody
    • PDL1 antibody
    • Programmed cell death 1 ligand 1 antibody
    • Programmed death ligand 1 antibody
    • RGD1566211 antibody
    see all

Anti-PD-L1 antibody [MIH5] (Biotin) 图像

  • Flow cytometric staining of C57Bl/6 splenocytes with 0.125 µg of Rat IgG2a Isotype Control Biotin (open histogram) or 0.125 µg of ab95792 (filled histogram), followed by Streptavidin PE. Total viable cells were used for analysis.

Anti-PD-L1 antibody [MIH5] (Biotin) (ab95792)参考文献

This product has been referenced in:
  • Sheng H  et al. A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res 18:846-57 (2008). Flow Cyt . Read more (PubMed: 18607390) »
  • Saudemont A  et al. NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells. Blood 105:2428-35 (2005). Read more (PubMed: 15536145) »

See all 3 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab95792.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"