概述

  • 产品名称PD 168077 maleate
  • 描述
    Potent, selective D4 agonist
  • 生物学描述Potent, selective D4 dopamine receptor agonist. Displays >400-fold selectivity over D2 and >300-fold selectivity over D3 subtypes (Ki values are 11.9, 2540, and 1050 nM for D4, D3, and D2 receptors, respectively). Reverses object recognition deficits.
  • 纯度> 98%
  • 常规说明

    This product appears to be unstable in ethanol solution

性能

  • 化学名称N-[4-(2-Cyanophenyl)-1-piperazinyl]methyl-3-methylbenzamide maleate
  • 分子量450.49
  • 化学结构Chemical Structure
  • 分子式C20H22N4O.C4H4O4
  • CAS编号190383-31-4
  • 存放说明Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 来源

    Synthetic

  • 研究领域

    PD 168077 maleate (ab120568)参考文献

    This product has been referenced in:
    • Sood P  et al. PD168077, a D(4) receptor agonist, reverses object recognition deficits in rats: potential role for D(4) receptor mechanisms in improving cognitive dysfunction in schizophrenia. J Psychopharmacol 25:792-800 (2011). Read more (PubMed: 21088042) »
    • Basso AM  et al. Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology 30:1257-68 (2005). Read more (PubMed: 15688083) »
    • Nayak S & Cassaday HJ The novel dopamine D4 receptor agonist (PD 168,077 maleate): doses with different effects on locomotor activity are without effect in classical conditioning. Prog Neuropsychopharmacol Biol Psychiatry 27:441-9 (2003). Read more (PubMed: 12691779) »

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