- 氨基酸679 to 692
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-PCSK9 antibody (ab28770)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Convertase subtilisin/kexin type 9 preproprotein
- 功能May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
- 组织特异性Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
- 疾病相关Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
- 序列相似性Belongs to the peptidase S8 family.
Contains 1 peptidase S8 domain.
- 翻译后修饰The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
Information by UniProt
PCSK9 peptide (679-692) (ab45712)参考文献
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"