Anti-PCSK9抗体[mAbcam84041] (ab84041)


  • 产品名称Anti-PCSK9抗体[mAbcam84041]
    参阅全部 PCSK9 一抗
  • 描述
    小鼠单克隆抗体[mAbcam84041] to PCSK9
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Non Human Primates
  • 免疫原

    Recombinant fragment derived from within residues 100 - 200 of Human PCSK9.

  • 阳性对照
    • This antibody gave a positive signal in human heart and human kidney tissue lysates.



Our Abpromise guarantee covers the use of ab84041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 74 kDa (predicted molecular weight: 74 kDa).
ICC/IF Use a concentration of 5 µg/ml.


  • 功能May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
  • 组织特异性Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
  • 疾病相关Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
  • 序列相似性Belongs to the peptidase S8 family.
    Contains 1 peptidase S8 domain.
  • 翻译后修饰The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Convertase subtilisin/kexin type 9 preproprotein antibody
    • FH3 antibody
    • HCHOLA3 antibody
    • Hypercholesterolemia autosomal dominant 3 antibody
    • LDLCQ1 antibody
    • NARC 1 antibody
    • NARC-1 antibody
    • NARC1 antibody
    • Neural apoptosis regulated convertase 1 antibody
    • Neural apoptosis-regulated convertase 1 antibody
    • PC 9 antibody
    • PC9 antibody
    • PCSK 9 antibody
    • PCSK9 antibody
    • PCSK9_HUMAN antibody
    • Proprotein convertase 9 antibody
    • Proprotein convertase PC9 antibody
    • Proprotein convertase subtilisin/kexin type 9 antibody
    • PSEC0052 antibody
    • Subtilisin/kexin like protease PC9 antibody
    • Subtilisin/kexin-like protease PC9 antibody
    see all

Anti-PCSK9 antibody [mAbcam84041] 图像

  • All lanes : Anti-PCSK9 antibody [mAbcam84041] (ab84041) at 1/500 dilution

    Lane 1 : Human heart tissue lysate - total protein (ab29431)
    Lane 2 : Human kidney tissue lysate - total protein (ab30203)

    Lysates/proteins at 20 µg per lane.

    Goat polyclonal Secondary Antibody to Mouse IgM (HRP) at 1/3000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 74 kDa
    Observed band size : 74 kDa
    Additional bands at : 30 kDa,40 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 1 minute
  • ICC/IF image of ab84041 stained Hek293 cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab84041, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 4% PFA fixed (10 min) HepG2 and MCF7 cells at 5µg/ml.

Anti-PCSK9 antibody [mAbcam84041] (ab84041)参考文献

ab84041 has not yet been referenced specifically in any publications.

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The antibodies you are interested in are provided following different purification steps. The ab84041 is provides as concentrated culture supernatant, ab5000 is provides as IgG fr...

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The Rabbit polyclonal to PCSK9 (ab125251; which we spoke about earlier is our only product that has been tested in ELISA. It recognizes a region around aa100-300 ...

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