概述

  • 产品名称Anti-PCSK9抗体
    参阅全部 PCSK9 一抗
  • 描述
    兔多克隆抗体to PCSK9
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Chimpanzee, Macaque Monkey, Gorilla, Marmoset (common)
  • 免疫原

    Synthetic peptide from Mouse PCSK9 amino acids 152-163

    VFAQSIPWNLER

  • 阳性对照
    • HepG2 cells

性能

应用

Our Abpromise guarantee covers the use of ab95478 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/50.
WB Use at an assay dependent dilution. Predicted molecular weight: 74 kDa.

靶标

  • 功能May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
  • 组织特异性Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
  • 疾病相关Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
  • 序列相似性Belongs to the peptidase S8 family.
    Contains 1 peptidase S8 domain.
  • 翻译后修饰The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Convertase subtilisin/kexin type 9 preproprotein antibody
    • FH3 antibody
    • HCHOLA3 antibody
    • Hypercholesterolemia autosomal dominant 3 antibody
    • LDLCQ1 antibody
    • NARC 1 antibody
    • NARC-1 antibody
    • NARC1 antibody
    • Neural apoptosis regulated convertase 1 antibody
    • Neural apoptosis-regulated convertase 1 antibody
    • PC 9 antibody
    • PC9 antibody
    • PCSK 9 antibody
    • PCSK9 antibody
    • PCSK9_HUMAN antibody
    • Proprotein convertase 9 antibody
    • Proprotein convertase PC9 antibody
    • Proprotein convertase subtilisin/kexin type 9 antibody
    • PSEC0052 antibody
    • Subtilisin/kexin like protease PC9 antibody
    • Subtilisin/kexin-like protease PC9 antibody
    see all

Anti-PCSK9 antibody 图像

  • ab95478 staining PCSK9 in HepG2 cells by immunofluorescence. The positive staining cytoplasm was visualized in red with a Cy3 conjugated goat anti-rabbit secondary antibody.

Anti-PCSK9 antibody (ab95478)参考文献

ab95478 has not yet been referenced specifically in any publications.

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