Anti-PCSK9抗体(ab125251)

概述

  • 产品名称Anti-PCSK9抗体
    参阅全部 PCSK9 一抗
  • 描述
    兔多克隆抗体to PCSK9
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Gorilla
  • 免疫原

    Synthetic peptide within Human PCSK9 aa 163-233. The exact sequence is proprietary.

  • 阳性对照
    • Whole cell lysates derived from HT-29, Mouse liver and Mouse lung.

性能

应用

Our Abpromise guarantee covers the use of ab125251 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 1 µg/ml. Predicted molecular weight: 74 kDa.
ELISA Use a concentration of 0.01 - 0.1 µg/ml.

靶标

  • 功能May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
  • 组织特异性Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
  • 疾病相关Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
  • 序列相似性Belongs to the peptidase S8 family.
    Contains 1 peptidase S8 domain.
  • 翻译后修饰The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Convertase subtilisin/kexin type 9 preproprotein antibody
    • FH3 antibody
    • HCHOLA3 antibody
    • Hypercholesterolemia autosomal dominant 3 antibody
    • LDLCQ1 antibody
    • NARC 1 antibody
    • NARC-1 antibody
    • NARC1 antibody
    • Neural apoptosis regulated convertase 1 antibody
    • Neural apoptosis-regulated convertase 1 antibody
    • PC 9 antibody
    • PC9 antibody
    • PCSK 9 antibody
    • PCSK9 antibody
    • PCSK9_HUMAN antibody
    • Proprotein convertase 9 antibody
    • Proprotein convertase PC9 antibody
    • Proprotein convertase subtilisin/kexin type 9 antibody
    • PSEC0052 antibody
    • Subtilisin/kexin like protease PC9 antibody
    • Subtilisin/kexin-like protease PC9 antibody
    see all

Anti-PCSK9 antibody 图像

  • All lanes : Anti-PCSK9 antibody (ab125251) at 1/500 dilution

    Lane 1 : HT29 whole cell lysates
    Lane 2 : Mouse liver whole lysates
    Lane 3 : Mouse lung whole lysates


    Predicted band size : 74 kDa

Anti-PCSK9 antibody (ab125251)参考文献

ab125251 has not yet been referenced specifically in any publications.

Product Wall

Application Immunoprecipitation
Sample Human Cell lysate - whole cell (HEK293 stable transfectants)
Total protein in input 48000 cells
Immuno-precipitation step Protein A/G
Specification HEK293 stable transfectants
Username

Meihui Pan

Verified customer

提交于 May 22 2015

The antibody is raised against an immunogen within the range of amino acids 163 - 233 of human PCSK9, which is part of the precursor as well as the active form. The single band detected on the blot of mouse liver was 64 kDa and is assumed to be the act...

Read More

I am waiting for the lab that provides this antibody to tell me where the immunogen is located within the range that is specified on the datasheet, aa 100 - 300. The proprotein is aa 31 - 152, and the mature protein is 153 - 692, using the numbering at...

Read More

Thank you for contacting us and your interest in our products.

The antibodies you are interested in are provided following different purification steps. The ab84041 is provides as concentrated culture supernatant, ab5000 is provides as IgG fr...

Read More

Thank you for contacting us.

The Rabbit polyclonal to PCSK9 (ab125251;http://www.abcam.com/PCSK9-antibody-ab125251.html) which we spoke about earlier is our only product that has been tested in ELISA. It recognizes a region around aa100-300 ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"