Anti-PCCB抗体(ab96729)
Key features and details
- Rabbit polyclonal to PCCB
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PCCB抗体
参阅全部 PCCB 一抗 -
描述
兔多克隆抗体to PCCB -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Pig, Zebrafish -
免疫原
Recombinant fragment, corresponding to a region within amino acids 167-450 of Human PCCB (NP_000523).
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阳性对照
- HepG2 whole cell lysate (ab7900) for WB and Lung Ad Cancer PC14 for IHC-P
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96729于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/100 - 1/250.
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WB |
1/500 - 1/3000. Predicted molecular weight: 58 kDa.
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说明 |
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IHC-P
1/100 - 1/250. |
WB
1/500 - 1/3000. Predicted molecular weight: 58 kDa. |
靶标
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通路
Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. -
疾病相关
Defects in PCCB are the cause of propionic acidemia type II (PA-2) [MIM:606054]. PA-2 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein. -
序列相似性
Belongs to the AccD/PCCB family.
Contains 1 carboxyltransferase domain. -
细胞定位
Mitochondrion matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 5096 Human
- Entrez Gene: 66904 Mouse
- Entrez Gene: 24624 Rat
- Omim: 232050 Human
- SwissProt: Q2TBR0 Cow
- SwissProt: P05166 Human
- SwissProt: Q99MN9 Mouse
- SwissProt: P79384 Pig
see all -
别名
- DKFZp451E113 antibody
- PCCase subunit beta antibody
- pccB antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab96729 被引用在 2 文献中.
- Zeng ZG et al. Therapeutic potential of living donor liver transplantation from heterozygous carrier donors in children with propionic acidemia. Orphanet J Rare Dis 17:62 (2022). PubMed: 35189944
- Strickaert A et al. Reprogramming of Energy Metabolism: Increased Expression and Roles of Pyruvate Carboxylase in Papillary Thyroid Cancer. Thyroid 29:845-857 (2019). PubMed: 30990120